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High Protein Mexican Taco Casserole

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High Protein Mexican Taco Casserole is the kind of dinner you make when you want something filling, but you don’t want a whole project. You just brown the beef, toss in a few pantry staples, layer it all in a dish, and let the oven do the heavy lifting.

It’s familiar and comforting. Plus, it’s easy to stretch if you need a little more out of dinner.

You can serve this recipe right away or stash it for later in the week. The layers actually hold together, so leftovers reheat without turning into a mess.

The ingredients are basic and easy to keep on hand. That makes this a solid pick for busy evenings when you didn’t really plan ahead.

If you like meals that come together in one dish and don’t need a bunch of sides, this casserole totally fits the bill. It’s simple enough for a weeknight, and honestly, it’s reliable enough to make again when you just want something that works.

High protein Mexican beef taco casserole baked in a clear glass baking dish with visible layers of seasoned ground beef, tortillas, tomato sauce, and evenly melted shredded cheese. The top is golden and bubbly with red sauce peeking through, shown in a close-up food photography style.

Why You’ll Love This High Protein Mexican Taco Casserole

High Protein

This casserole is loaded with lean ground beef and black beans, making it a great option for anyone who wants a filling, high protein dinner.

Family-Friendly

With mild spices and classic Mexican flavors, this is a meal both kids and adults will eat without complaint.

Easy Prep

There’s nothing complicated here. The ingredients are simple, and you just layer everything together and bake.

Healthy Ingredients

Using extra lean ground beef, non-fat sour cream, and reduced-fat cheese keeps this casserole lighter without losing taste.

High protein Mexican beef taco casserole baked in a clear glass baking dish with layers of seasoned ground beef, tortillas, and tomato sauce. The top is evenly covered with melted shredded cheese, lightly browned and bubbly, with red sauce and beef visible along the edges in a kitchen setting.

Ingredient Substitutions

Ground Beef

You can use ground turkey or ground chicken instead of beef for a lighter option.

Tortillas

Swap corn tortillas for flour tortillas or use a gluten-free version if needed.

Cheese

Any shredded cheese blend will work if you don’t have Mexican cheese blend.

Black Beans

Pinto beans or kidney beans can be used in place of black beans.


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High protein Mexican beef taco casserole baked in a clear glass baking dish with visible layers of seasoned ground beef, tortillas, tomato sauce, and evenly melted shredded cheese. The top is golden and bubbly with red sauce peeking through, shown in a close-up food photography style.

High Protein Mexican Taco Casserole

Nesting Lane
High Protein Mexican Taco Casserole with lean ground beef, tortillas, beans, and melted cheese baked in one dish.
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Prep Time 10 minutes
Cook Time 40 minutes
Total Time 50 minutes
Course Main Course
Cuisine Mexican
Servings 6

Ingredients
 

Instructions
 

  • Preheat the oven to 350°F.
  • Place a large skillet over medium-high heat.
  • Add the chopped onion and ground beef to the skillet.
  • Cook until the beef is browned and fully cooked.
  • Transfer the beef mixture to a colander.
  • Rinse with warm water and allow it to drain.
  • Return the beef mixture to the skillet.
  • Add the diced tomatoes to the skillet.
  • Add the corn to the skillet.
  • Add the jalapeños to the skillet.
  • Add the black beans to the skillet.
  • Sprinkle the taco seasoning over the mixture.
  • Stir until everything is evenly mixed.
  • Reduce the heat to low. Simmer for 5 minutes.
  • Lightly coat a 2-quart baking dish with cooking spray.
  • Cut the corn tortillas in half.
  • Place 8 tortilla halves in the bottom of the baking dish, overlapping slightly.
  • Spoon half of the beef mixture over the tortillas.
  • Spread the sour cream evenly over the beef layer.
  • Place the remaining tortilla halves over the sour cream.
  • Spoon the remaining beef mixture on top.
  • Place the baking dish in the oven.
  • Bake for 25 minutes.
  • Remove the dish from the oven.
  • Sprinkle the cheese evenly over the top.
  • Sprinkle cilantro over the cheese.
  • Cover the dish and allow it to rest for about 5 minutes so the cheese melts.

Notes

Tips and Tricks

Layering – Overlap the tortillas slightly so the base holds together after baking.
Draining the Beef – Rinsing the cooked beef helps keep the casserole from becoming greasy.
Cheese Melting – Covering the dish after baking allows the cheese to melt evenly without overbaking.

Storing and Reheating

Refrigerator – Store leftovers in an airtight container in the refrigerator for up to 4 days.
Reheat on Stovetop – Place a serving in a saucepan with 1 to 2 tablespoons water. Warm over low heat, stirring until heated through.
Oven Reheat – Place portions in an oven-safe dish, cover, and warm at 325°F until hot.

Nutrition

Serving: 346gCalories: 355.4kcalCarbohydrates: 52.3gProtein: 26.7gFat: 5.9gSaturated Fat: 2.2gCholesterol: 49.7mgSodium: 814.7mgFiber: 10.4gSugar: 82g
Tried this recipe? Let us know what you think!Mention @nestinglane or tag #nestinglane
High protein Mexican beef taco casserole baked in a clear glass baking dish, layered with seasoned ground beef, tortillas, tomato sauce, and melted shredded cheese. Close-up shows a cheesy, bubbly top with red and golden tones. Text on image reads “HIGH PROTEIN Mexican Beef Taco Casserole” and “SAVE FOR LATER” with “NESTINGLANE.COM” at the bottom.